Discovering New Therapeutic Targets and Molecular Pain Mechanisms Using Human Tissues: Recent Advances, Emerging Pitfalls, Continuing Gaps in Knowledge

Home / Event

Date and Time

Tuesday, 4 August 2020
08:30 – 16:45

Location

E104 (RAI Amsterdam)

Fee

Additional Fee Required


Event/Session Summary

Discovering New Therapeutic Targets and Molecular Pain Mechanisms Using Human Tissues: Recent Advances, Emerging Pitfalls, Continuing Gaps in Knowledge

 
Full Day SIG Satellite Symposium
Hosted By: Neuropathic Pain SIG (NeuPSIG)

Major advances have been made in our understanding of pain mechanisms using animal models over the past several decades, but this knowledge base has not resulted into translation into new therapeutics. The increasing use of human tissues such as dorsal root ganglia and skin biopsy promises to facilitate the translation process by not only better validating animal model discoveries but by providing a heretofore under-utilized discovery engine. New tools to gain unprecedented molecular insight into human donor and patient samples are rapidly expanding, as are tissue and organ donor resources to obtain these tissue samples.

The goal of this NeuPSIG-sponsored satellite meeting will be to bring together leading laboratories from throughout the world that are focusing on these new and rapidly expanding areas of research. The meeting will bring together expertise in genetics, RNA sequencing, molecular tissue analysis, electrophysiology, neuropathology and induced pluripotent stem cells (iPSCs) from all disciplines of science in NeuPSIG.

While the focus will be to present the most up-to-date science in molecular and cellular neurobiology of human primary sensory neurons and their projection targets such as skin, the overarching goal will be to unify diverse methods and fields of study into broad resources that can enhance therapeutic development for neuropathic pain. We envision this satellite meeting as a transformational starting point for the field where mechanism-based discovery research shifts focus from animal models to human tissues.

Preliminary Agenda

 08:30

Opening Remarks


 08:45-10:15

Session 1: Recent Findings from Peripheral Tissues, Nerve Endings and Peripheral Axons

Chair: Aki Hietaharju, MD, Finland 
 
Correlates of Neuropathic Pain at Distal Endings of Human DRG Neurons: Studies from Human Skin Biopsy

Claudia Sommer, MD (Germany)

Investigating the Role of Keratinocytes in Painful Small Fiber Neuropathy Using Human Primary Cultures
Margarita Calvo, MD, PhD (Chile)

Molecular Mechanisms of Pain in Human Entrapment Neuropathies
Annina Schmidt, PhD (United Kingdom)

Pain Mechanisms in Human Distal Nerve Terminals
TBD: Early Career/Trainee Talks

General Discussion/Q&A

 10:15-10:30

Morning Coffee Break

 10:30-12:00
Session 2: Recent Findings from Human DRG Neurons

Chair: Srnivasa Raja, MD (USA)

 
                          
Pharmacological Studies of Human DRG Neurons: A Platform for Validation of New Therapeutics 

Robert Gereau, III, PhD (USA)

Ectopic Discharges in Human DRG Somata and Spontaneous Pain: Data on Underlying Mechanisms
Patrick Dougherty, PhD (USA)

Single Cell Transcriptomic Findings from Human DRG
Steve Davidson, PhD (USA)

Other Findings in Human DRG 
TBD: Early Career/Trainee Talks

General Discussion/Q&A

 12:00-13:00

Lunch Break

 13:00-14:30  
Session 3: Recent Findings from Human iPSC-derived Neurons

Chair: Simon Hartounian, MD (USA)

                     
Translation of Preclinical Mechanisms of Neuropathic Pain in Human iPSC-derived Neurons  

David Bennett, PhD (United Kingdom)

Sodium Channel Mechanisms of Neuropathic Pain Modelled in Human iPSC-Derived Neurons
Angelika Lampert (Germany)

Physiology & Neurochemistry of Human iPSC-derived Neurons 

TBD: Early Career/Trainee Talks

General Discussion/Q&A

 14:30-15:00

Afternoon Coffee Break

 15:00-16:30
Session 4: More Findings using Human iPSC-derived neurons and Transcriptomic Findings in Human Sensory Neurons

Chair: Nanna Finnerup, MD (Denmark)

 
              
Correlates and Differences Between Physiology Studies in Human DRG and iPSC-derived Neurons

Michael Gold, PhD (USA)

Transcriptomic Findings from Human DRG: Bulk Seq, Single Cell Seq and Patch Seq Findings
Theodore Price, PhD (USA)

Transcriptomic Findings in Human Spinal Neurons
Alex Chamessian, MD (USA)

Transciptomic Findings in Human Sensory Neurons
TBD: Early Career/Trainee Talks

General Discussion/Q&A

 16:30-16:45

Closing Remarks

 


Registration Rates

All rates listed in USD

 Registration Type

Rate (USD)

 IASP Member

$85

 Nonmember

$140

 IASP Trainee Member

$60

 IASP Member from a Developing
 Country*

$60


*The Developing Country rate is available to residents of countries with a gross national income of less than $15,000,
as defined by the World Bank.