Assessing Conditioned Pain Modulation in Humans as a Proxy for the Efficacy of Descending Inhibitory Circuitries

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Date and Time

Tuesday, 4 August 2020
08:30 – 12:00


RAI Theater Stage (RAI Amsterdam)


Additional Fee Required

Event/Session Summary

Assessing Conditioned Pain Modulation in Humans as a Proxy for the Efficacy of Descending Inhibitory Circuitries

Hands-On Workshop

Conditioned pain modulation (CPM), as measured in humans, is a unique example of an endogenous descending modulatory pathway that, in the normal situation, acts to inhibit pain responses when activated by a noxious stimulus in a remote body region. Diffuse noxious inhibitory controls (DNIC) are the proposed pre-clinical paradigm, as measured in rodents. Both CPM and DNIC are activated by the application of a noxious conditioning stimulus, and this is distal to the test stimulus; in this way ‘pain inhibits pain’. 

Stations & Faculty

How to Measure CPM: The Thermal Protocol  
David Yarnitsky, MD (Israel)
David Yarnitsky will provide a hands-on experience with complete performance of a thermal parallel CPM protocol, consisting of two test stimuli (mechanical and heat) and a single conditioning stimulus (cold water immersion). 

Assessing CPM on Deep Tissue Pain: The Mechanical Protocol 
Thomas Graven-Nielsen,  PhD, DMSc (Denmark)
Thomas Graven-Nielsen will demonstrate the methodology for assessing CPM with deep-tissue pain conditioning and test stimuli, provided with a computer-controlled and user-independent cuff algometer. 

Reliability, Measurement Error and Statistical Methods: Analysing CPMOutputs  
Rie Bager Hansen and Donna Kennedy, MSc (United Kingdom)
Rie Bager Hansen and Donna Kennedy will determine in real time the CPM effect measured in paradigms at stations 1 and 2 and will discuss statistical methods for categorizing CPM effect as inhibitory or facilitatory as well as evidence for CPM reliability in healthy volunteer and clinical cohorts. 

Diffuse Noxious Inhibitory Controls: Measuring the Proposed Pre-Clinical Paradigm of CPM in Rat
Kirsty Bannister, PhD (United Kingdom)
Kirsty Bannister will guide delegates through a pre-recorded example of the DNIC assay in rat.


All rates listed in USD

 Registration Type


 IASP Member




 IASP Trainee Member


 Nonmember Trainee


 IASP Member from a Developing Country*


 Nonmember from a Developing Country*


*The Developing Country rate is available to residents of countries with a gross national income of less than $15,000,
as defined by the World Bank.